A new zinc chelator, IPZ-010 ameliorates postoperative ileus
نویسندگان
چکیده
منابع مشابه
Postoperative Ileus A SPECIAL ARTICLE
13 INTRODUCTION Postoperative ileus (POI) is a very common problem after many surgical procedures, may lead to significant patient morbidity, and is a common reason for gastroenterological consultation. POI may be generally defined as transient inhibition of normal GI motility in the postoperative setting, typically lasting 3-5 days after surgery. Clinical consequences of POI include worsened p...
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Purpose. The efficacy, safety, pharmacology, pharmacokinetics, drug–drug interactions, and administration of alvimopan for postoperative ileus are reviewed. Summary. Alvimopan is a selective mopioid receptor antagonist with no central nervous system activity. When orally administered after partial smallor largebowel resection in patients with primary anastomosis, alvimopan shortened the return ...
متن کاملA single intraperitoneal dose of carbon monoxide-saturated ringer's lactate solution ameliorates postoperative ileus in mice.
Treatment with inhaled carbon monoxide (CO) has been shown to ameliorate bowel dysmotility caused by surgical manipulation of the gut in experimental animals. We hypothesized that administration of CO dissolved in lactated Ringer's solution (CO-LR) might provide similar protection to that observed with the inhaled gas while obviating some of its inherent problems. Postoperative gut dysmotility ...
متن کاملManagement of postoperative ileus.
Postoperative ileus, a temporary cessation in bowel motility, is a common and significant complication of major surgery. Consequences of postoperative ileus include increased patient discomfort, delayed time to adequate nutrition, prolonged length of stay, and increased cost to the patient and healthcare system. The traditional, multi-modal approach to the resolution of postoperative ileus incl...
متن کاملPostoperative Ileus: Pathophysiology and Treatment
Postoperative ileus (POI) is a temporary impairment of gastrointestinal (GI) motility occurring universally after major abdominal surgery (Holte & Kehlet, 2002). For the majority of affected surgical patients, POI is transient, lasting approximately 3 to 5 days (Hotokezaka, et al., 1997). The adverse effects of POI are composed of not only physiologic effects such as reduced bowel function, exa...
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ژورنال
عنوان ژورنال: Biomedicine & Pharmacotherapy
سال: 2020
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2019.109773